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Cameron Rupp drove in the tiebreaking run with a sacrifice fly and the Philadelphia Phillies scored four times in the 10th inning to beat the scuffling New York Mets 6-2 on Tuesday night.

Odubel Herrera homered early for the Phillies, who took advantage of a pivotal error by third baseman Jose Reyes and handed the Mets their fourth straight defeat. Reyes dropped a two-out popup in the eighth before pinch-hitter Andres Blanco tied it at 2 with an RBI double off reliever Jerry Blevins.

With All-Star closer Jeurys Familia set to return from a domestic violence suspension Thursday, the Mets’ bullpen was beaten again after Zack Wheeler pitched five solid innings, allowing one run in his third start after missing the previous two seasons while recovering from Tommy John surgery.

New York’s past five games have been decided in the winning team’s final at-bat, including three losses at Miami last weekend.

Michael Saunders led off the 10th with an infield single that ricocheted off reliever Rafael Montero’s foot. Tommy Joseph singled to right field, sending Saunders to third. Rupp’s long fly to the warning track in right scored Saunders to give Philadelphia a 3-2 lead.

Pinch-hitter Aaron Altherr followed Freddy Galvis’ single with a base hit of his own, driving in Joseph for the Phillies’ fourth run and chasing Montero (0-2).

Daniel Nava broke it open against Sean Gilmartin with a two-run single to make it 6-2.

Luis Garcia (1-0) pitched a scoreless ninth for the win.

After being swept by New York at home last week, the Phillies took advantage of a beleaguered Mets bullpen that is 0-4 with a 7.15 ERA during the four-game skid.

Notes: Mets right-handed pitcher Seth Lugo (partially torn ligament in pitching elbow) and lefty Steven Matz (left elbow inflammation) are both scheduled to begin throwing programs on Wednesday. … Third baseman David Wright (neck surgery) is set to resume baseball activities in the next day or two after stopping for a short period due to the flu and some discomfort in his lower back, according to general manager Sandy Alderson.

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